TMS vs Spravato: Which Treatment Is Right for My Depression?


If you or a loved one is struggling with depression, you may have come across two innovative treatment options: Transcranial Magnetic Stimulation (TMS) and Spravato (Esketamine). Both treatments offer hope for individuals dealing with treatment-resistant depression, but they work in different ways and have unique benefits and drawbacks.


In this article, we’ll dive deep into TMS vs Spravato to help you understand what questions to ask to identify the right option for you.

Understanding TMS and Spravato

Depression is a complex mental health condition that can be difficult to treat. While traditional antidepressant medications with or without psychotherapy work for some, others may find little to no relief. This is where new and alternative treatments like TMS and Spravato come into play.


Both of these treatments are FDA-approved and designed to help individuals who have not responded well to conventional antidepressants. However, their mechanisms of action, effectiveness, and suitability differ significantly.

What is TMS (Transcranial Magnetic Stimulation)?

TMS is a non-invasive procedure that uses magnetic pulses to stimulate specific areas of the brain associated with mood regulation. This process helps to improve communication between neurons, thereby alleviating symptoms of major depressive disorder (MDD).


A typical TMS session involves placing a coil on the patient’s scalp, which delivers painless magnetic pulses to targeted regions of the brain. Unlike medications, TMS does not introduce chemicals into the body, making it a popular option for individuals who have difficulty tolerating the side effects that may come with medications.

Benefits of TMS

TMS offers several key benefits:

  • Non-invasive treatment: No surgery, no anesthesia, and no systemic side effects like those that may be caused by medication.
  • Minimal side effects: The most common side effects include mild headache or scalp discomfort, which usually subside with time.
  • High success rate: Many individuals experience long-term relief from depression symptoms after completing a TMS treatment course.
  • No dependency risk: TMS does not pose a risk of dependence or addiction.
  • FDA-approved for depression: Recognized as a safe and effective treatment option for treatment-resistant depression.

Who is TMS For?

TMS is ideal for individuals who:

  • Have not responded to at least two different antidepressants.
  • Prefer a non-drug alternative for managing depression.
  • Do not have a history of seizures or metal implants in the head, which may interfere with treatment.Have not responded to at least two different antidepressants.

What is Spravato (Esketamine)?

Spravato is a nasal spray containing esketamine, a compound derived from ketamine, designed specifically for individuals with treatment-resistant depression (TRD). Unlike traditional antidepressants, which can take weeks or months to work, Spravato provides rapid relief by increasing glutamate levels in the brain, which helps restore damaged neural connections.


Spravato must be administered under medical supervision in a certified healthcare setting due to its potential for side effects, including disassociation, dizziness and high blood pressure.

Benefits of Spravato

Spravato provides several unique advantages:



  • Fast-acting relief: Some patients experience improvements within hours of the first dose. 
  • Appropriate for severe depression: Particularly beneficial for those with suicidal thoughts and severe depressive symptoms.
  • Alternative for medication-resistant individuals: Helps people who haven’t found relief through traditional antidepressants.

Who is Spravato For?

Spravato may be a suitable option for individuals who:



  • Have tried at least two different antidepressants without success.
  • Need rapid relief from depression symptoms.
  • Can commit to supervised treatment sessions in a medical setting.

Comparing TMS vs Spravato

Both treatments are designed for treatment-resistant depression, but they differ in terms of

how they work and what they offer.

Effectiveness of TMS vs Spravato

  • TMS provides long-term symptom relief but requires daily sessions over several weeks before significant improvements are seen.
  • Spravato offers fast relief, often within hours, but the effects may be short-lived without ongoing treatments.
  • Studies suggest TMS has a higher long-term success rate compared to Spravato, especially for individuals looking for sustainable recovery.

Side Effects of TMS and Spravat

While both treatments are generally safe, they have different potential side effects:


  • TMS side effects are minimal and may include mild headaches, scalp discomfort, or temporary lightheadedness.
  • Spravato side effects can be more intense, including dizziness, nausea, disassociation, and an increased risk of misuse or dependency.

Cost Comparison: TMS vs Spravato

  • TMS is often covered by insurance for individuals with treatment-resistant depression. 
  • Spravato is expensive and requires ongoing treatments, making it less affordable for some individuals.
  • Out-of-pocket costs vary, but TMS is generally more cost-effective over time due to its long-lasting benefits.

Which Treatment is Right for You?

Deciding between TMS vs Spravato depends on several factors:


  • Severity of Depression: If you need rapid relief from severe symptoms, Spravato may be the better choice. If you’re looking for a potentially longer lasting benefit, TMS might be more beneficial.
  • Tolerance for Side Effects: Some individuals prefer TMS because it does not involve disassociation or nausea, which are common with Spravato.
  • Cost & Insurance Coverage: TMS is more likely to be covered by insurance, making it a more accessible option for many individuals.

What Irvine Psychiatry and TMS Offers

At Irvine Psychiatry and TMS, we specialize in personalized cutting-edge depression treatments, including TMS and Spravato. Our team of experienced professionals will assess your unique needs and recommend the most effective treatment plan for you.

SHARE pOST:

RECENT POST:

May 8, 2026
When you're struggling with your mental health, the last thing you should have to fight is your own insurance company. But for thousands of Californians, that fight is their reality, and a recent class action lawsuit is highlighting the reasons behind it. In November 2025, four policyholders filed a lawsuit against Blue Shield of California and Magellan Health, alleging that they maintained what's known as a "ghost network" of mental health providers. According to the complaint, the insurance companies published directories listing psychiatrists and therapists who either don't exist, have moved on, or simply don't accept new patients. When real people in real crisis tried to use their coverage, they found nothing on the other end. The lawsuit puts it plainly: "When people in need are unable to find an in-network mental health provider, urgent mental health treatment is often delayed and, at worst, abandoned completely." That sentence should stop you in your tracks. What is a ghost network and why does it matter? A ghost network is an insurance provider directory that looks robust on paper but falls apart the moment a patient tries to access it. You call the first name on the list and get an out-of-service number. You call the second and hear they're not accepting new patients. You call the third and they've never heard of your insurance plan. You are not able to get the services you need from the network that you are covered by. You either give up and don’t get treatment, your symptoms worsen and you end up in emergency care before you can find an in network doctor, or you pay for care out of pocket. Meanwhile, the insurance company benefits. They attract customers with the appearance of comprehensive mental health coverage. They collect high premiums. And they don’t pay out claims because the doctors that would generate those claims don't actually exist in any functional sense. This should be unacceptable to all those involved. The people hurt most by this are not statistics. They are someone's parent, partner, or child. When people need help, and ask for help, they deserve to find help, not to be sent on a wild goose chase that leads to a dead end. This is a mental health access crisis Mental health care is not optional. Conditions like anxiety, depression, OCD, PTSD, and bipolar disorder are medical realities that require real treatment, not a runaround. Delaying care doesn't make these conditions go away. It makes them worse. This ends up costing us in many other ways. For most patients, the window between deciding to seek help and actually getting it is narrow. Every disconnected phone number and every full practice is a door closing on someone who was ready to open one. The downstream consequences, including worsening symptoms, emergency interventions, and hospitalization, cost the system far more than timely outpatient care ever would. And they cost patients something money can't replace. Ghost networks are not a billing technicality. They are a public health issue. And they are illegal. Know your rights as a mental health patient in California If you're covered by a Blue Shield of California policy and encountered barriers finding an in-network mental health provider, you may be part of the class described in this lawsuit. Speaking with a consumer rights or insurance attorney can help you understand your options. More broadly, here is what every patient should know. Your insurance plan is required by law to maintain an accurate, up-to-date provider directory. Under California and federal mental health parity laws, your insurer must provide mental health coverage no more restrictive than coverage for comparable physical health conditions. You have the right to request an out-of-network exception if your insurer cannot connect you with an available in-network provider. You can file a complaint with the California Department of Managed Health Care at dmhc.ca.gov if your insurer fails to provide timely access to mental health care. Don't accept "no available providers" as a final answer. Real psychiatric care in Irvine and Orange County Dr. Roula Creighton established Irvine Psychiatry and TMS to serve this community with genuine, personalized psychiatric care. We are not a name on a list that leads nowhere. We are a functioning practice with over 20 years of experience, a real team, and real availability for patients who need us. We treat a wide range of conditions including depression, anxiety, OCD, PTSD, bipolar disorder, ADHD, eating disorders, and substance use disorders, using evidence-based approaches that include psychotherapy, medication management, TMS therapy, and Spravato. We also offer telehealth appointments for patients who cannot come in person. If you have been bounced around by your insurance network and are still looking for care, we encourage you to reach out. We will work with you to understand your coverage, explore your options, and make sure the process of getting help doesn't become another barrier. We have many out of network contracts with Blue Shield of California to treat patients that are covered by their plans but can’t find someone in network. Mental health treatment should be accessible. At Irvine Psychiatry and TMS, we are committed to making it exactly that. Explore our services and take the first step toward real care in Orange County. See Our Services | Request an Appointment
April 12, 2026
For many women in Orange County, the expectation to "do it all" is constant. Whether you are navigating a high-stakes career in the Irvine Business Complex, managing a household in Northwood, or balancing both, the mental load can be overwhelming. However, for women, mental health is often uniquely tied to biological transitions that are frequently misunderstood or dismissed. At Irvine Psychiatry, we recognize that women’s mental health requires a specialized lens. From the hormonal fluctuations of the reproductive years to the significant shifts of menopause, your biological health and your mental well-being are inextricably linked. The Hormonal Connection: Beyond "Just Being Emotional" For decades, women’s psychiatric symptoms were regularly minimized. Today, we know that hormones like estrogen and progesterone interact directly with brain chemicals like serotonin and dopamine. With the natural fluctuations of these hormones during the menstrual cycle, pregnancy, or perimenopause, we see a significant impact on mood, anxiety levels, and cognitive function. PMDD: More Than Just PMS Premenstrual Dysphoric Disorder (PMDD) is a severe, sometimes disabling extension of PMS. It can cause extreme mood shifts, hopelessness, and intense irritability that disrupt work and relationships. Our approach at Irvine psychiatry focuses on distinguishing PMDD from other depressive illnesses to help understand your unique scenario and ensure you receive targeted treatment that actually works. The Perimenopause and Menopause Transition The transition into menopause is one of the most significant biological shifts a woman will experience. The drop in estrogen can lead to numerous symptoms including "brain fog," increased anxiety, irritability and new-onset depressive symptoms. We work with women in this phase to help them understand and manage these symptoms, often using a combination of precision psychiatry and coordination with their OB/GYN. Postpartum Mental Health: Support for New Moms in Irvine and the Surrounding Area The "Baby Blues" are common, but Postpartum Depression (PPD) and Postpartum Anxiety (PPA) are serious conditions that require professional intervention. In a culture that pressures new mothers to "bounce back" immediately, seeking help can feel stigmatized. We provide a safe, compassionate space for new mothers to address: Intrusive Thoughts: Scary, repetitive thoughts that are often a symptom of postpartum OCD or anxiety. Loss of Identity: Navigating the massive life shift that comes with a new child. Bonding Struggles: Helping moms manage the guilt and biological hurdles that can interfere with the early months of motherhood. The "Silent" Pressure: The Mental Load of the OC Lifestyle Beyond biology, women in Irvine often carry a disproportionate "mental load", the invisible labor of planning, organizing, and remembering everything for a family or a team. The ever increasing expectations to do more, schedule more and always appear unfrazzled is difficult to live up to. This chronic stress can lead to burnout, which often mirrors the symptoms of clinical depression. High-functioning anxiety is particularly prevalent in our community. You may be succeeding at work and showing up for every school event, yet feel a constant sense of dread or "imposter syndrome" on the inside. Our goal is to help you set healthy boundaries and develop coping mechanisms that protect your peace without sacrificing your ambitions. A Personalized Approach to Treatment At Irvine Psychiatry and TMS, we believe that every woman's journey is unique. Our treatment plans are not "one size fits all." We offer a spectrum of care tailored to your specific needs and life stage: Targeted Medication Management We understand the nuances of prescribing for women, including how certain medications interact with birth control or how they may need to be managed during pregnancy and breastfeeding. Interventional Options (TMS) For women who are unable to tolerate the systemic side effects of medication such as weight gain or fatigue, Transcranial Magnetic Stimulation (TMS) offers a drug-free alternative. It is particularly effective for treatment-resistant depression and has shown great promise in helping women find relief when traditional treatments have failed. Holistic and Integrative Support We look at the whole picture, including sleep hygiene, nutritional support, and stress-reduction techniques that fit into a busy Orange County schedule. You Don’t Have to Carry the Weight Alone Your mental health is the foundation of everything else you do. Taking care of yourself isn’t selfish; it’s necessary for your health, your family, and your career. Whether you are struggling with hormonal transitions or the weight of daily stress, our Irvine-based team is here to listen and provide expert, compassionate care. Schedule a Consultation at Our Irvine Office If you are ready to explore a psychiatry practice that truly understands the complexities of women's mental health, we invite you to reach out. Located at The Atrium on Von Karman Avenue, we provide a calming, professional environment where you can feel heard and supported. Contact us today to begin your path toward a more balanced, vibrant life.
March 19, 2026
For those living with Obsessive-Compulsive Disorder (OCD), life can feel like being trapped in that repetitive loop. Whether it is the intrusive thoughts that won’t stay quiet or the physical compulsions that feel impossible to ignore, OCD is more than just a personality trait—it is a biological condition that impacts the brain’s circuitry. In a high-pressure environment like Orange County, the need for control can make OCD symptoms even more taxing. While many patients in Irvine have tried traditional psychotherapy or Cognitive Behavioral Therapy (CBT) or high-dose SSRIs, nearly 40% of people with OCD do not find full relief from these first-line treatments. At Irvine Psychiatry and TMS , we are bridging that gap with Transcranial Magnetic Stimulation (TMS) —a non-invasive, FDA-approved technology that targets the specific pathways in the brain that are overactive in OCD. The Science of the "Stuck" Brain Cycle To understand why OCD is difficult to treat, we have to look at the brain's "cortico-striato-thalamo-cortical" (CSTC) circuit. In a healthy brain, this circuit helps you transition from a thought to an action and then "click" into a feeling of completion. In the brain of someone with OCD, this circuit becomes hyperactive. It gets "stuck" in this repetitive loop, causing the brain to send continuous error signals (obsessions) that lead to repetitive behaviors (compulsions) in an attempt to find relief. Traditional talk therapy works on the "software" of the brain, but for many, the "hardware" itself—the physical neural pathway—needs a reset. How TMS Targets OCD Differently Than Depression Many people have heard of TMS as a treatment for depression, but the protocol for OCD is distinct. While depression treatment usually targets the prefrontal cortex to "wake up" or stimulate underactive circuits, OCD treatment often targets the supplementary motor area (SMA) and the anterior cingulate cortex (ACC) . The pulse rate is also usually different. Instead of fast paced activating pulses, OCD treatment involves slow and consistent pulses. By using focused magnetic pulses, TMS helps to "calm" the overactive circuits responsible for intrusive thoughts. This has been shown to help the brain "unstick" itself, making it easier for patients to engage in therapy and resist compulsions. The Benefits of a Non-Medication Approach One of the biggest hurdles in treating OCD is the side effects of medications. To treat OCD effectively, psychiatrists often have to prescribe SSRIs at much higher doses than what is used for depression. This can lead to more side effects, including: Weight gain and metabolic changes. Physical fatigue or "emotional blunting." Sexual dysfunction. TMS offers a powerful alternative. Because it is a localized treatment using magnetic fields, it does not enter the bloodstream and carries none of these systemic side effects. You can complete a 20-minute session at our Irvine office and drive right back to work or pick up your kids, with no "brain fog" or downtime. What to Expect During OCD Treatment at Irvine Psychiatry and TMS Choosing a new medical treatment can be intimidating, which is why we prioritize a transparent, supportive environment. We work with you to review if TMS is the best next treatment option. We will make sure you’re comfortable with the steps involved. The Clinical Mapping: Your first session involves "brain mapping," where we identify the precise location and intensity needed for your specific brain structure. The Treatment Pulse: During the session, you will feel a firm but painless tapping sensation. Most patients spend this time meditating or chatting with our technicians. The Timeline: For OCD, the FDA-cleared protocol typically involves sessions five days a week for about six weeks. Many patients begin to notice a "quieting" of their intrusive thoughts by week three or four. Integration: TMS and Exposure Response Prevention (ERP) At Irvine Psychiatry, we don’t view TMS as a replacement for therapy, but as a powerful "accelerant." When the physical intensity of an obsession is lowered by TMS, patients often find that their Exposure and Response Prevention (ERP) therapy becomes significantly more effective. You are no longer fighting your own brain chemistry; you are working with it. Take Control of Your OCD at our practice in Orange County If you feel like you’ve exhausted the standard options for OCD and you are not seeing improvement, it’s time to look at the frontier of interventional psychiatry. Our Irvine clinic is equipped with the latest TMS technology, and our team is dedicated to helping you find a path out of the loop. Don't let OCD dictate your schedule, your relationships, or your peace of mind any longer. Contact Irvine Psychiatry and TMS today to see if you are a candidate for TMS therapy.